Historical function
Pearl medicinal has been in China for more than 2,000 years. The medical books of the Three Kingdoms, "Medical Doctors", Liangdai's "Materia Medica", the Tang Dynasty's "Hai Yao Materia Medica", the Song Dynasty's "Kai Bao Materia Medica", the Ming Dynasty's "Compendium of Materia Medica", the Qing Dynasty's "Lei Gong Yao Fu "19 ancient medical books, such as the ancient Chinese medicine, have a clear record of the efficacy of pearls.
Liang Daitao Hongjing said in the "Materia Medica Collection" that the pearl "has the effect of treating the skin and stopping the phlegm". The "Hai Yao Materia Medica" of the Tang Dynasty believed that pearls can be eye-catching, fainting, and venting. In the Yuan Dynasty, merchants often added honey and pearl powder in the water to drink, thinking that it can nourish and prevent heatstroke. Yuan Haowen recorded in the "Continuation of Yi Jian": "The water is cold and the ice is cold in the winter... It is as clean as a pearl... In the summer, it is adjusted with honey water and pearl powder."
In the Ming Dynasty, Li Shizhen paid more attention to the pharmacological effects of pearls. He believed that the efficacy of pearls was in the skin of the skin. Therefore, in the "Compendium of Materia Medica", it was specially written: "The pearls are salty and sweet, non-toxic, and the eyes are sharp; the pearls are coated and moisturized. Good color. Apply the hands and feet, go to the skin to reverse the sputum; fall sputum, in addition to facial spots, diarrhea; in addition to children with convulsions, soothe the soul; stop the fine white turbid, acne treatment. ... so that the gloss is white and so on. At the same time, it also records a variety of methods for the medicinal use of pearls.
In the Ming Dynasty, Chen Jiru quoted "Independence" as saying that when Tang Wuzong Li Yan was in office, the prime minister Li Deyu used jewel powder, realgar and cinnabar decoction as a simmer. Each cup of food cost about 30,000 yuan, and after three fried, the slag was discarded. At that time, popular alchemy, people believe that pearl powder, realgar and other things, after refining, can be immortal, crane hair and children.
Modern function
"People's Republic of China Pharmacopoeia" and "Chinese Medicine Dictionary" all indicate that pearls have the effects of calming the nerves, clearing the eyes, detoxifying and stimulating the muscles. Modern research also shows that pearls improve human immunity, delay aging, whitening and whitening. Calcium and other aspects have a unique role.
Relieve the nerves, clear the heat and nourish the yin, eyesight, detoxification.
1. The heart of the town is shocked and suitable for convulsions and seizures.
2. Qinggan, in addition to phlegm and eyesight, with eye diseases such as redness and swelling, aponeurosis and other eye diseases.
3. Converging myogenic muscles, suitable for throat rot, mouth sores, ulcers for a long time, not suitable for external use.
Pharmacological action
1. Inhibition of lipofuscin and scavenging free radicals: mice intraperitoneal injection of pearl powder suspension 200mg / (kg. days) × 25 days, can significantly reduce the content of lipofuscin in myocardium and brain tissue, no liver tissue Significant impact. The PFC extracted from the triangular pearl powder and its separated product were determined by chemiluminescence method for the free radical of O. The results showed that both of them inhibited the luminescence, and the monomer component PCM-1 after PFC purification had stronger effect, which could inhibit the free radical reaction in vivo.
2. Anti-tumor effect: mice were intraperitoneally injected with PFC 40mg/(kg.day)×9 days, and the mice were subcutaneously inoculated with S180 sarcoma cells 8.0×10 5/ml (P<0.01), and the inhibition rate was 34.8%. The same dose of the drug inhibited subcutaneous inoculation of Lewis lung cancer homogenate 5.0 × 10 / ml of mice, the inhibition rate was 13.89%, but there was no statistical difference. The same dose of drugs can prolong the survival time of mice immunized with P388/J lymphocytic leukemia by 14.75% (P<0.05), and significantly reduce the spleen weight of animals by 24.12% (P<0.01). For P388/J cells cultured in vitro, PFC 50μg/ml and 100μg/ml in the two dose groups, the killing rate at 72 hours after administration was 25.0% and 24.8%, respectively (P<0.01).
3. Other effects: The pearl extract has an inhibitory effect on the isolated rabbit intestine.
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